Table 1 MMV688533 activity (in nanomolar) against Plasmodium parasite lines and field isolates.

In vitro activity against Plasmodium culture-adapted lines or field isolates was calculated from dose-response curves and is shown as median or mean half-maximal growth inhibition (IC50) in nanomolar concentrations. For the laboratory lines, numbers of independent repeats are shown in parentheses. 3D7 and FC27 are chloroquine sensitive, whereas Dd2 and K1 are chloroquine resistant. The potency of the other antimalarials was compared to MMV688533 using a Wilcoxon rank sum test.

Laboratory
lines
Laboratory
lines
Laboratory
lines
Laboratory
lines
Clinical field
isolates
(Uganda)
Clinical field
isolates (Papua,
Indonesia)
Clinical field
isolates (Papua,
Indonesia)
P. falciparumP. falciparumP. falciparumP. falciparumP. falciparumP. falciparumP. vivax
Antimalarial3D7
(Median, N)
Dd2
(Median, N)
FC27
(Mean, N)
K1
(Mean, N)
Median
(N; range)
Median
(N; range)
Median
(N; range)
MMV6885331.9 (4)3.0 (4)9.7 (2)19 (2)1.3
(143; 0.02–6.3)
18.9
(15; 5.3–39.2)
12.0
(6; 5.4–19.9)
Chloroquine11 (11)347 (10)10.9 (2)100.3 (2)17***
(143; 2.1–346)
64.8***
(15; 38.3–283)
36.4*
(6; 11.6–114)
Piperaquine4.4 (11)7.9 (10)25.8 (2)111.2 (2)5.1***
(140; 0.3–26)
60.8***
(15; 17.6–130)
46.6*
(6; 15.0–135)
Mefloquine4.8 (11)6.6 (10)37.2 (2)8 (2)8.3***
(120; 0.5–24)
10.0
(15; 4.9–41.9)
11.2
(6; 8.1–20.7)
DHA/artesunate1.9 (9)1.7 (9)0.6 (2)1.1 (2)1.5
(142; 0.1–9.0)
1.2***
(15; 0.4–4.3)
0.6*
(6; 0.3–2.4)

*P < 0.05.

***P < 0.001.

†DHA was tested on 3D7, Dd2, and Ugandan parasites, whereas artesunate was tested on FC27, K1 and Papua/Indonesian parasites.