Table 1 Clinical signs observed in African green monkeys inoculated with irradiated or infectious SARS-CoV-2.

Animals were observed daily according to a standardized scoring sheet (19); the same person assessed the animals throughout the study. N/A, not available.

InoculumAnimalClinical signs observed
1 to 3 dpi
Clinical signs observed
4 to 10 dpi
Observations at necropsy
Irradiated SARS-CoV-2AGM1Reduced appetite.N/ANone.
Euthanized 3 dpi.
AGM2Reduced appetite.N/ANone.
Euthanized 3 dpi.
SARS-CoV-2AGM3Reduced appetite.N/AGross lung lesions; cervical and
mediastinal lymph nodes enlarged.
Euthanized 3 dpi.
AGM4Tachypnea; reduced appetite.N/AGross lung lesions; mediastinal
lymph nodes mildly enlarged.
Euthanized 3 dpi.
AGM5Tachypnea; reduced appetite.N/AGross lung lesions; mediastinal
lymph nodes enlarged.
Euthanized 3 dpi.
AGM6Reduced appetite.N/AGross lung lesions; mediastinal
lymph nodes enlarged.
Euthanized 3 dpi.
AGM7Reduced appetite.Reduced appetite.Gross lung lesions; mediastinal
lymph nodes enlarged.
Recovered at 5 dpi.
AGM8Hunched posture; tachypnea;
severely reduced appetite.
Hunched posture; tachypnea;
severely reduced appetite.
Lungs consolidated; mediastinal
lymph nodes enlarged and
hemorrhagic.
Recovered at 9 dpi.
AGM9Tachypnea; reduced appetite.Tachypnea; reduced appetite.Gross lung lesions; mediastinal
lymph nodes enlarged.
Recovered at 6 dpi.
AGM10Hunched posture; tachypnea;
coughing; reduced appetite.
Reduced appetite.None.
Recovered at 5 dpi.