Table 1 Somatic mutations detected in donors that were predicted to be pathogenic according to CADD.

Six mutations were found to be associated with various malignancies, and three were specifically associated with hematologic malignancies (*).

GeneTypeAmino acid changeCADDCOSMICEngrafted
COL12A1Missensep.I530L22.1COSM271996Yes
CREBBPMissensep.T1242I25.5Yes
DNMT3ANonsensep.W288X40COSM1130818Yes
DNMT3AMissensep.R174S26.5Yes
DNMT3AMissensep.G398R30COSM256035*Yes
DNMT3AMissensep.I158M23.6Yes
DNMT3AMissensep.Q222P26.1Yes
DNMT3AMissensep.H669P23.3Yes
FAT1Missensep.D1554N25.8COSM1429043Yes
SRCAPIndelT:TGCTTCGCC29Yes
STAG2Missensep.Y188D26.3Yes
TET2Splicingc.3954 + 1G > A34COSM87141*Yes
TET2Missensep.Y1345C32Yes
TP53Missensep.R150W25.7COSM99925*Yes
USP34Missensep.H1874R22.5Yes
WT1Missensep.R74W28.7Yes