Table 1 Sensitivity and specificity of the cfDNA methylation test for colonoscopy findings.

Colonoscopy findingPatients (n = 1493)ctDNA methylation test (n = 1493)
Positive resultsNegative resultsSensitivitySpecificity
CRCNo.No.No.% (95% CI)% (95% CI)
Stage I–III CRC2119290.5 (72.7–97.8)
High-grade dysplasia87187.5 (47.4–99.7)
All CRC89.7 (72.7–97.8)
Advanced
precancerous lesion*
78265233.3 (23.1–44.9)66.7 (55.1–76.9)
Nonadvanced
adenoma
114258921.9 (14.7–30.7)78.1 (69.4–85.3)
Other benign lesions250202308.0 (4.9–12.1)92.0 (87.9–95.1)
Negative on
colonoscopy
101212388987.9 (85.7–89.8)
All nonadvanced
adenoma and
non-neoplastic findings
and negative results on
colonoscopy
1386168121887.9 (86.0–89.6)
All noncancer1464194127086.8 (84.9–88.4)

*Advanced precancerous lesion includes the following: villous adenoma, adenoma >1.0 cm in size, and sessile serrated polyps >1.0 cm in size.