Parameter based onnoncompartmentalanalysis | LYA (n = 39) | LYB (n = 42) |

Estimate | Estimate | |

Steady-state C_{max}(ng/ml)* | 722 (67.0%) | 7930 (75.5%) |

Steady-state C_{trough,ss}(ng/ml)* | 436 (77.8%) | 3080 (68.2%) |

Steady-state t_{max}(hours)^{†} | 3.13 (0.85–5.33) | 3.07 (0.75–4.68) |

Parameter based onpopulation PKanalyses | Population estimate | Population estimate |

CL/F (liters/hour)^{‡} | 3.12 (2.66–3.71) | 7.18 (5.45–8.42) |

V/F (liters)^{‡} | 39.5 (35.5–50.2) | 89.3 (34.7–141) |

t_{1/2} (hours)^{§} | 8.78 | 8.62 |

AUC_{ss,24hr} (mg·hour/liter)║ | 15.3 (38.7) | 115 (35.0) |

*Reported as geometric mean [geometric %CV (percent coefficient of variation)].

†Reported as median (range).

‡Reported as mean (95% confidence interval).

§Derived using the population estimate of CL/F and V/F based on the following equation: log(2)/(CL/V).

║Reported as geometric mean (%CV), calculated using the post hoc estimate of CL/F of each patient, following the equation dose/(CL/F).