Table 2 Regression analyses for the effects of CSF sTREM2 concentrations on the rate of change in the ADNI-MEM and ADAS-cog scores and in hippocampal volume.

All models are controlled for age, gender, education, CSF p-tau181 × time, CSF-Aβ1–42 × time, CSF sTREM2, CSF Aβ1–42, CSF p-tau181 (fixed effects) plus random slope (time) and intercept. Regular P values were assessed using Satterthwaite’s method. For nonparametric confirmation of results, P values were further assessed using permutation testing with 1000 iterations (P-perm.). B, regression coefficient; CI, confidence interval; T value, t test statistic; Cohen’s d, effect size d; P-perm., P value from permutation test.

ADNI-MEMInteraction termB (SE)95% CIT valueCohen’s dPP-perm.
CN A−T−CSF sTREM2 × time0.036 (0.046)−0.052–0.125<1NA0.4290.395
CSF sTREM2/p-tau × time0.043 (0.043)−0.042–0.127<1NA0.3310.312
All A+T+CSF sTREM2 × time0.071 (0.022)0.028–0.1133.2580.430.0010.020
CSF sTREM2/p-tau × time0.088 (0.020)0.049–0.1284.3540.55<0.001<0.001
MCI A+T+CSF sTREM2 × time0.071 (0.028)0.017–0.1252.5810.410.0110.046
CSF sTREM2/p-tau × time0.092 (0.025)0.043–0.1413.6630.57<0.0010.004
AD dementia
A+T+
CSF sTREM2 × time0.050 (0.023)0.006–0.0942.1940.620.0330.027
CSF sTREM2/p-tau × time0.059 (0.022)0.016–0.1032.6710.730.0090.006
ADAS13Interaction termB (SE)95% CIT valueCohen’s dPP-perm.
CN A−T−CSF sTREM2 × time0.087 (0.047)−0.006–0.1791.849NA0.0740.084
CSF sTREM2/p-tau × time0.070 (0.043)−0.015–0.1571.626NA0.1150.151
All A+T+CSF sTREM2 × time−0.076 (0.035)−0.145–−0.007−2.1370.280.0340.045
CSF sTREM2/p-tau × time−0.102 (0.033)−0.167–−0.037−3.0780.380.0020.023
MCI A+T+CSF sTREM2 × time−0.076 (0.046)−0.165–0.013−1.672NA0.0960.205
CSF sTREM2/p-tau × time−0.105 (0.042)−0.186–−0.024−2.5300.390.0120.033
AD dementia
A+T+
CSF sTREM2 × time−0.047 (0.054)−0.151–0.056<1NA0.3840.352
CSF sTREM2/p-tau × time−0.076 (0.054)−0.181–0.029−1.402NA0.1660.137
Hippocampal volumeInteraction termB (SE)95% CIT valueCohen’s dPP-perm.
CN A−T−CSF sTREM2 × time−0.010 (0.013)−0.046–0.016<1NA0.4450.382
CSF sTREM2/p-tau × time−0.007 (0.013)−0.032–0.018<1NA0.6060.552
All A+T+CSF sTREM2 × time0.023 (0.010)0.004–0.0432.3180.390.0220.024
CSF sTREM2/p-tau × time0.023 (0.009)0.005–0.0412.5330.410.0120.024
MCI A+T+CSF sTREM2 × time0.034 (0.013)0.008–0.0602.5630.490.0120.010
CSF sTREM2/p-tau × time0.030 (0.012)0.007–0.0532.5800.490.0110.010
AD dementia
A+T+
CSF sTREM2 × time−0.004 (0.023)−0.047–0.040−0.159NA0.8740.888
CSF sTREM2/p-tau × time0.0001 (0.001)−0.0001–0.0003<1NA0.9990.999