Table 1 Erythroferrone, hepcidin, and SF3B1 mutation as independent predictors of hyperferritinemia in low transfusion burden patients with MDS.

Erythroferrone, hepcidin, sTfR, number of RBC units per 8 weeks, and SF3B1 mutation were evaluated in the group of 60 patients receiving less than 4 RBC units per 8 weeks on the basis of ferritin with a cutoff value of 300 ng/ml. Parameters are indicated as means and 95% confidence intervals (95% CI) or ranges. For univariate analysis, Mann-Whitney and χ2 tests were used to compare the variables between SF3B1MUT and SF3B1WT MDS. Multivariate logistic regression analysis was performed for variables with P value < 0.1 in univariate analysis.

ParametersFerritin < 300 ng/mlFerritin ≥ 300 ng/mlUnivariateMultivariate
n = 19n = 41P valueP value
Erythroferrone (ng/ml),
mean (95% CI)
36.7 (26.8–46.6)72.7 (55.4–90.0)0.0050.002
Hepcidin (ng/ml), mean
(95% CI)
17.2 (11.2–23.2)35.9 (25.9–45.9)0.013<0.0001
sTfR (ng/ml), mean (95% CI)1.21 (0.99–1.43)1.42 (1.18–1.65)0.484
Number of RBC units/
8 weeks, mean (range)
0.2 (0–2)0.6 (0–3)0.104
SF3B1 mutation yes, n (%)3 (15.8)22 (53.6)0.0060.023