Fisher’s exact test was used to test whether the distribution of individuals randomized to the treatment conditions differed by sex and by ethnicity; no significant effects were found. For age, IQ, pretreatment SRS-2 T score, pretreatment CGI-S score, pretreatment blood AVP concentration (in picograms per milliliter), and pretreatment blood AVPR1A:OXTR gene expression, differences between treatment conditions were tested with a simple one-way general linear model; no significant effects were discerned. The values are reported as means ± SE. F, female; M, male; IQ, Intelligence Quotient; SRS-2, Social Responsiveness Scale, 2nd Edition; CGI-S, Clinical Global Impression-Severity; AVP, arginine vasopressin AVPR1A:OXTR, relative gene expression as the ΔΔCt of AVPR1A and OXTR gene expression.
Treatment | n | Sex | Ethnicity | Age (years) | Full-scale IQ score | SRS-2 T score | CGI-S score | Blood AVP concentration | Blood AVPR1A: OXTR | ||
F | M | Caucasian | Other | ||||||||
AVP | 17 | 3 | 14 | 8 | 9 | 9.14 ± 0.57 | 77.65 ± 5.03 | 78.12 ± 1.66 | 4.82 ± 0.15 | 1.32 ± 0.25 | 2.25 ± 0.31 |
Placebo | 13 | 2 | 11 | 11 | 2 | 9.86 ± 0.65 | 91.85 ± 5.76 | 83.00 ± 1.90 | 4.77 ± 0.17 | 1.28 ± 0.29 | 2.21 ± 0.35 |