Table 1 Demographics of AREST CF and non-CF disease control populations.

See the Supplementary Materials for definitions of infection and pathogens. P values are calculated by Student’s t test for parametric variables, Mann-Whitney for nonparametric variables, and by χ2 for discrete variables.

CFNon-CFP
Subjects, n4616
Age, years3.3 ± 1.73.2 ± 2.00.837
Gender, male (%)19 (41%)11 (69%)0.083
CFTR mutations, F508del
homozygous
25 (54%)
CFTR mutations, residual function2 (4.3%)
Study visits, n (range per subject)62 (1–3)16 (1)
BALF samples, n12432
BALF TCC, ×106 cells/ml (RML only)6.7 ± 7.21.3 ± 1.0<0.001
BALF % neutrophils (RML only)18.6 ± 22.34.4 ± 5.1<0.001
Antibiotic treatment*43 (69%)7 (44%)0.080

*Antibiotics within 3 months of bronchoscopy.