Table 2 Plasma concentrations of tylosin A analogs after single oral dosing in mice and gerbils.

CompoundSpeciesDose (mg/kg)AUC0-inf (ng┬Ěhr/
ml) (SEM)
A-1535469BALB/c mice307800 (1620)
10036100 (2910)
A-1574083BALB/c mice2517.9 (0.85)
50271 (23.7)
752153 (1089)
Gerbils8.9260.9 (15.5)
473646 (619)
82.25169 (478)
1499200 (276)