Table 1 Summary of centyrin panning campaign.

Target
leukocidin
Panning output*Selective
neutralizers†
Cross-reactive
neutralizers‡
LukABLukAB binders: 2610
LukEDLukE binders: 7172 (LukED and
HlgAB)
LukD binders: 44
HlgABHlgA binders: 5130
HlgB binders: 13
HlgCB16234 (HlgCB and
LukSF-PV)
HlgC binders: 309
LukSF-PV
(PVL)
LukS binders: 2298
LukF binders: 28

*Clones of unique binders, from library variants of TENCON, of target leukocidins by in vitro library selection system (CIS display).

†Purified centyrins found to selectively neutralize cytotoxicity on hPMNs by leukocidins.

‡Purified centyrins found to neutralize cytotoxicity on hPMNs by two leukocidin.