Table 2 Biodistribution of 68Ga-DOTA-GGNle-CycMSHhex on M21 human melanoma–xenografted nude mice.

The data are presented as percent injected dose/gram (%ID/g) or as percent injected dose (%ID) (means ± SD, n = 4).

Tissues0.5 hour1 hour2 hours1 hour
NDP-MSH
blockade
% ID/g
Tumor6.05 ± 0.836.07 ± 0.685.15 ± 0.781.02 ± 0.54*
Brain0.09 ± 0.020.06 ± 0.010.04 ± 0.020.05 ± 0.02
Blood1.78 ± 0.440.69 ± 0.190.41 ± 0.210.52 ± 0.12
Heart0.80 ± 0.170.31 ± 0.030.17 ± 0.020.24 ± 0.07
Lung1.86 ± 0.280.8 ± 0.10.3 ± 0.040.57 ± 0.09
Liver0.97 ± 0.150.57 ± 0.030.45 ± 0.070.5 ± 0.03
Skin2.0 ± 0.340.94 ± 0.210.62 ± 0.120.37 ± 0.23
Spleen0.54 ± 0.040.36 ± 0.050.21 ± 0.090.28 ± 0.23
Stomach0.80 ± 0.240.32 ± 0.070.46 ± 0.40.25 ± 0.07
Kidneys6.61 ± 1.114.09 ± 0.493.74 ± 0.553.76 ± 0.39
Muscle0.37 ± 0.10.15 ± 0.030.11 ± 0.030.08 ± 0.02
Pancreas0.43 ± 0.160.2 ± 0.030.14 ± 0.050.19 ± 0.08
Bone1.06 ± 0.30.37 ± 0.10.35 ± 0.110.26 ± 0.24
% ID
Intestines1.24 ± 0.360.68 ± 0.130.61 ± 0.270.51 ± 0.04
Urine77.35 ± 4.0388.91 ± 0.6692.75 ± 1.1393.4 ± 1.34
Uptake ratio of tumor/
normal tissue
Tumor/blood3.48.8012.561.96
Tumor/
kidney
0.921.481.380.27
Tumor/lung3.257.5917.171.79
Tumor/liver6.2410.6511.442.04
Tumor/
muscle
16.3540.4746.8212.75

*P < 0.05, tumor uptake with or without peptide blockade at 1 hour after injection.