Table 2 Biodistribution of ⁶⁸Ga-DOTA-GGNle-CycMSH_hex on M21 human melanoma–xenografted nude mice.

The data are presented as percent injected dose/gram (%ID/g) or as percent injected dose (%ID) (means ± SD, n = 4).

Tissues	0.5 hour	1 hour	2 hours	1 hour NDP-MSH blockade
		% ID/g
Tumor	6.05 ± 0.83	6.07 ± 0.68	5.15 ± 0.78	1.02 ± 0.54*
Brain	0.09 ± 0.02	0.06 ± 0.01	0.04 ± 0.02	0.05 ± 0.02
Blood	1.78 ± 0.44	0.69 ± 0.19	0.41 ± 0.21	0.52 ± 0.12
Heart	0.80 ± 0.17	0.31 ± 0.03	0.17 ± 0.02	0.24 ± 0.07
Lung	1.86 ± 0.28	0.8 ± 0.1	0.3 ± 0.04	0.57 ± 0.09
Liver	0.97 ± 0.15	0.57 ± 0.03	0.45 ± 0.07	0.5 ± 0.03
Skin	2.0 ± 0.34	0.94 ± 0.21	0.62 ± 0.12	0.37 ± 0.23
Spleen	0.54 ± 0.04	0.36 ± 0.05	0.21 ± 0.09	0.28 ± 0.23
Stomach	0.80 ± 0.24	0.32 ± 0.07	0.46 ± 0.4	0.25 ± 0.07
Kidneys	6.61 ± 1.11	4.09 ± 0.49	3.74 ± 0.55	3.76 ± 0.39
Muscle	0.37 ± 0.1	0.15 ± 0.03	0.11 ± 0.03	0.08 ± 0.02
Pancreas	0.43 ± 0.16	0.2 ± 0.03	0.14 ± 0.05	0.19 ± 0.08
Bone	1.06 ± 0.3	0.37 ± 0.1	0.35 ± 0.11	0.26 ± 0.24
		% ID
Intestines	1.24 ± 0.36	0.68 ± 0.13	0.61 ± 0.27	0.51 ± 0.04
Urine	77.35 ± 4.03	88.91 ± 0.66	92.75 ± 1.13	93.4 ± 1.34
		Uptake ratio of tumor/ normal tissue
Tumor/blood	3.4	8.80	12.56	1.96
Tumor/ kidney	0.92	1.48	1.38	0.27
Tumor/lung	3.25	7.59	17.17	1.79
Tumor/liver	6.24	10.65	11.44	2.04
Tumor/ muscle	16.35	40.47	46.82	12.75

*P < 0.05, tumor uptake with or without peptide blockade at 1 hour after injection.