Table 1 Biodistribution of ⁶⁸Ga-DOTA-GGNle-CycMSH_hex on B16/F10 murine melanoma–bearing C57 mice.

The data are presented as percent injected dose per gram (%ID/g) or as percent injected dose (%ID) (means ± SD, n = 4).

Tissues	0.5 hour	1 hour	2 hours	1 hour NDP-MSH blockade
		%ID/g
Tumor	18.63 ± 4.97	24.27 ± 3.74	11.61 ± 2.87	1.94 ± 0.51*
Brain	0.13 ± 0.02	0.07 ± 0.01	0.03 ± 0.01	0.09 ± 0.06
Blood	2.27 ± 0.32	0.83 ± 0.1	0.31 ± 0.06	0.98 ± 0.45
Heart	0.94 ± 0.06	0.36 ± 0.04	0.12 ± 0.02	0.35 ± 0.04
Lung	1.91 ± 0.22	0.87 ± 0.12	0.29 ± 0.02	0.73 ± 0.19
Liver	1.21 ± 0.08	0.79 ± 0.08	0.61 ± 0.06	0.69 ± 0.08
Skin	2.26 ± 0.12	1.23 ± 0.33	0.54 ± 0.19	0.8 ± 0.17
Spleen	0.75 ± 0.08	0.36 ± 0.05	0.33 ± 0.15	0.22 ± 0.15
Stomach	1.67 ± 0.87	0.91 ± 0.11	0.54 ± 0.16	0.49 ± 0.36
Kidneys	9.22 ± 1.38	7.78 ± 0.63	6.01 ± 0.91	5.98 ± 0.69
Muscle	0.44 ± 0.03	0.3 ± 0.05	0.13 ± 0.08	0.36 ± 0.24
Pancreas	0.44 ± 0.07	0.24 ± 0.05	0.11 ± 0.07	0.4 ± 0.19
Bone	0.98 ± 0.27	0.6 ± 0.13	0.24 ± 0.15	0.32 ± 0.22
		%ID
Intestines	1.32 ± 0.51	0.68 ± 0.11	0.59 ± 0.31	0.68 ± 0.31
Urine	71.62 ± 11.72	85.39 ± 3.76	91.73 ± 0.26	91.83 ± 1.01
		Uptake ratio of tumor/ normal tissue
Tumor/blood	8.21	29.24	37.45	1.98
Tumor/ kidney	2.02	3.12	1.93	0.32
Tumor/lung	9.75	27.90	40.03	2.66
Tumor/liver	15.40	30.72	19.03	2.81
Tumor/ muscle	42.34	80.90	89.31	5.39

*P < 0.05, tumor uptake with or without peptide blockade at 1 hour after injection.