Table 1 Biodistribution of 68Ga-DOTA-GGNle-CycMSHhex on B16/F10 murine melanoma–bearing C57 mice.

The data are presented as percent injected dose per gram (%ID/g) or as percent injected dose (%ID) (means ± SD, n = 4).

Tissues0.5 hour1 hour2 hours1 hour
NDP-MSH
blockade
%ID/g
Tumor18.63 ±
4.97
24.27 ± 3.7411.61 ± 2.871.94 ± 0.51*
Brain0.13 ± 0.020.07 ± 0.010.03 ± 0.010.09 ± 0.06
Blood2.27 ± 0.320.83 ± 0.10.31 ± 0.060.98 ± 0.45
Heart0.94 ± 0.060.36 ± 0.040.12 ± 0.020.35 ± 0.04
Lung1.91 ± 0.220.87 ± 0.120.29 ± 0.020.73 ± 0.19
Liver1.21 ± 0.080.79 ± 0.080.61 ± 0.060.69 ± 0.08
Skin2.26 ± 0.121.23 ± 0.330.54 ± 0.190.8 ± 0.17
Spleen0.75 ± 0.080.36 ± 0.050.33 ± 0.150.22 ± 0.15
Stomach1.67 ± 0.870.91 ± 0.110.54 ± 0.160.49 ± 0.36
Kidneys9.22 ± 1.387.78 ± 0.636.01 ± 0.915.98 ± 0.69
Muscle0.44 ± 0.030.3 ± 0.050.13 ± 0.080.36 ± 0.24
Pancreas0.44 ± 0.070.24 ± 0.050.11 ± 0.070.4 ± 0.19
Bone0.98 ± 0.270.6 ± 0.130.24 ± 0.150.32 ± 0.22
%ID
Intestines1.32 ± 0.510.68 ± 0.110.59 ± 0.310.68 ± 0.31
Urine71.62 ±
11.72
85.39 ± 3.7691.73 ± 0.2691.83 ±
1.01
Uptake ratio of tumor/
normal tissue
Tumor/blood8.2129.2437.451.98
Tumor/
kidney
2.023.121.930.32
Tumor/lung9.7527.9040.032.66
Tumor/liver15.4030.7219.032.81
Tumor/
muscle
42.3480.9089.315.39

*P < 0.05, tumor uptake with or without peptide blockade at 1 hour after injection.