Table 2 Association between the analytes and all assessed measures in HD mutation carriers.

Values are Pearson’s r generated by partial correlations including age, or age and CAG, as covariates. Significant associations highlighted in bold. Volumetric measures are percentage of total intracranial volume (TIV).

Clinical measures
(n = 60)
Adjusted forCSF mHTTCSF NfLPlasma NfL
rP valuerP valuerP value
Total functional capacityAge−0.3540.0060−0.3580.0054−0.512<0.0001
Age and CAG−0.1220.3618−0.0380.7785−0.2910.0267
Total motor scoreAge0.4440.00040.533<0.00010.695<0.0001
Age and CAG0.2080.11810.2490.05940.525<0.0001
Symbol digit modalities testAge−0.3330.0108−0.4630.0003−0.562<0.0001
Age and CAG−0.0610.6551−0.1400.2985−0.3290.0125
Stroop color namingAge−0.3510.0064−0.509<0.0001−0.650<0.0001
Age and CAG−0.0720.5931−0.2080.1166−0.4540.0003
Stroop word readingAge−0.3880.0024−0.528<0.0001−0.702<0.0001
Age and CAG−0.1080.4178−0.2190.0989−0.525<0.0001
Verbal fluency categoricalAge−0.3700.0040−0.4450.0004−0.577<0.0001
Age and CAG−0.0970.4672−0.1030.4401−0.3400.0091
Imaging measures
(n = 49)
Whole-brain volumeAge−0.2340.1102−0.4790.0006−0.4060.0042
Age and CAG−0.0820.5862−0.4520.0014−0.2850.0518
White matter volumeAge−0.1420.3360−0.3540.0135−0.2050.1626
Age and CAG−0.0530.7246−0.3510.0157−0.1220.4150
Gray matter volumeAge−0.2660.0674−0.5070.0002−0.4770.0006
Age and CAG−0.1510.3116−0.3980.0057−0.4040.0049
Caudate volumeAge−0.2110.1547−0.5390.0001−0.718<0.0001
Age and CAG−0.0250.8682−0.3580.0144−0.628<0.0001