Table 1 Comparison of analyte concentrations.

Intergroup differences were assessed using multiple linear regressions, which included either age or age and CAG as covariates. Significant differences are in bold. P values are Bonferroni-corrected. NfL concentrations were natural log–transformed. Values are means ± SD. CAG, CAG repeat length; ANOVA, analysis of variance; N/A, not applicable.

AnalyteControl
(n = 20)
PreHD
(n = 20)
Manifest HD
(n = 40)
Comparison P values
Adjusted forControl
versus all
mutation
carriers
ANOVAControl
versus PreHD
PreHD versus
manifest HD
CSF mHTT (fM)0 ± 046.4 ± 21.873.7 ± 28.7Age<0.0001<0.0001<0.00010.0010
Age and CAGN/AN/AN/A0.1520
CSF NfL
(log pg/ml)
6.7 ± 0.57.5 ± 0.78.5 ± 0.4Age<0.0001<0.0001<0.0001<0.0001
Age and CAGN/AN/AN/A0.0148
Plasma NfL
(log pg/ml)
2.9 ± 0.43.3 ± 0.64.2 ± 0.4Age<0.0001<0.0001<0.0001<0.0001
Age and CAGN/AN/AN/A0.0008