Table 1 WES analyses and somatic mutation loads.
Tumor type*Number of
samples
CerebroTCGA MC3
Median
mutation load
% Load
> 100
% Load
> 250
% Load
> 500
% Load
> 1000
Median
mutation load
% Load
> 100
% Load
> 250
% Load
> 500
% Load
> 1000
Lung
adenocarcinoma
(LUAD)
47314160.329.48.92.115262.831.310.12.1
Lung squamous
cell (LUSC)
13417882.827.66.71.518884.334.37.51.5
Bladder (BLCA)36013664.423.15.61.1141.565.023.95.81.1
Enriched for high–mutation load tumors
Liver (LIHC-H)1417525.53.51.40.07224.13.51.40.7
Melanoma
(SKCM-H)
10530870.557.133.39.531771.458.135.211.4
Colon (COAD-H)44786.588.665.963.634.1892.588.661.459.145.5
Uterine (UCEC-H)417846.346.326.80.07846.346.322.00.0
Kidney renal clear
cell (KIRC-H)
25648.00.00.00.0620.00.00.00.0
Head and neck
(HNSC-H)
15493100.086.746.713.3486100.093.346.713.3
Stomach (STAD-H)6998100.0100.0100.050.0872.5100.0100.0100.050.0
Sarcoma (SARC-H)5540100.0100.060.00.052260.060.060.00.0
Other-H1973484.273.768.436.866894.784.268.436.8

*-H, tumor samples enriched for high mutation load.