Table 2 Safety assessment of 20 patients 24 months after hDPSC implantation

ALT, alanine aminotransferase; AST, aspartate aminotransferase.

1234567891011121314151617181920NormalUnit
ALT16122133243310352217233115394041252121319–50IU/liter
AST191527322623163524202219272325383123293215–40IU/liter
Total protein70.670.279.082.566.471.666.072.768.970.169.277.172.480.178.278.278.478.477.674.365.0–85.0g/liter
Globulin24.528.230.530.721.823.022.725.723.531.232.429.431.828.231.530.428.127.330.436.520.0–40.0g/liter
Albumin46.142.048.551.844.648.643.347.045.448.949.643.750.948.649.447.548.950.250.347.440.0–55.0g/liter
Total bilirubin10.611.212.811.49.39.511.97.97.411.58.513.612.78.510.510.210.39.712.611.63.4–20.5μM
Direct bilirubin4.45.26.75.14.95.15.93.42.95.24.32.45.54.93.85.65.65.85.65.00.0–6.8μM
Indirect bilirubin6.26.06.16.34.44.46.04.54.56.34.74.95.45.25.35.34.94.95.25.64.3–6.4μM
Alkaline phosphatase200170195201210196205212188175798614785787810015010117420–220IU/liter
γ-Glutamyltransferase123949561227354116453537475150495554545810–60IU/liter
Albumin/globulin1.91.51.61.72.12.11.91.81.91.31.81.71.52.02.12.02.01.92.01.91.2–2.4
Urea4.104.705.704.902.852.952.773.102.983.04.844.895.205.435.515.016.015.216.016.012.50–6.30mM
Creatinine11262905867101829557897977681029811110998879853–115μM
Uric acid310336356335198194184236168255188355322283301305299241314354150–430μM
Lactate dehydrogenase198213209145160206198191132217172172174179198179187197178241120–250IU/liter
Creatine kinase1241052302077692226616722315421119823321120425424121327450–310IU/liter
Creatine kinase
isoenzyme
1919131213111791216111814192019171622170–24IU/liter
Cystatin C0.720.950.790.600.660.620.780.630.560.980.740.880.720.920.871.010.831.010.780.870.55–1.05mg/liter
T cell (%)79.7074.3571.0868.3164.3280.0171.0368.7064.9081.0470.2570.1272.0485.0071.0069.0584.0569.2575.1470.4556–86%
CD4+ T (%)51.2748.2849.3248.2951.2754.3253.4555.7156.1156.0255.0353.1049.5648.2454.0049.5649.3255.2554.2348.7233–58%
CD8+ T (%)18.2318.1320.9416.2320.9416.0315.9415.0715.0416.4417.9817.2217.0914.2316.0117.0015.0917.0415.9817.2213–19%
B cell (%)11.5712.8310.8915.2111.5710.4314.2117.1718.1319.0420.0019.0619.4521.0119.0020.0020.8818.1118.1118.045–22%
NK cell (%)5.435.215.677.635.436.097.437.437.0110.2319.0514.5515.0120.1215.2321.3616.2120.0114.1018.365–26%
CD4+/CD8+2.452.162.241.972.452.062.012.081.982.072.272.092.022.412.001.991.861.452.001.990.71–2.78
Lymphocyte count214325212019251321432512220125712963273229052689301229013014310032152159240131041530–3700/μl
Total T cell count17051489139714691705195318021985247120192601244124012543260124001987244722212210723–2737/μl
CD4+ T cell count13201180133814021318140313401408106514771258150112781500130013681379139813651357404–1612/μl
CD8+ T cell count5394285676974895064486417657398458018047007008011001987871803220–1129/μl
B cell count198201182231154132276251274301515403401310414400201314258135880–616/μl
NK cell count939897103999510510912111610520221212013415023128919817784–724/μl
Antistreptolysin O69.75432.744.255.850.719.9069.7020.0056.3047.724.477.438.952.976.347.632.766.351.5<116IU/ml
C-reactive protein0.250.300.350.170.290.150.180.250.700.370.510.190.450.620.660.610.440.220.340.43<0.80mg/dl
Rheumatoid factor4.924.504.023.645.908.922.554.9210.9010.058.1215.713.78.912.4013.408.408.6516.57.78<20IU/ml
IgA110.4132.499.889.4110125.5100.9110.4335.2129.432578.4223.8307.4112.7228.690.698.4240.7164.782–453mg/dl
IgG843.5833.8798.5801.5855.5806.5946.2843.51110.58911154859.5919.1874.5866.81239.5874.3944.21012.81321.2751–1560mg/dl
IgM62.452.755.178.674.668.278.562.4190.3162.6176.996.764.3196.8186.4174.3154.278.562.6123.640–274mg/dl
C383.992.979.581.9107.186.1120.183.988.7113.1123.7102.4107.6100.792.197.887.3100.490.788.479–152mg/dl
C416.92318.61819.91922.716.927.618.521.620.328.327.625.830.222.919.729.128.416–38mg/dl