Table 1 Progressive disease at week 13 according to MHC class I and MHC class II thresholds in CheckMate 064.
BiomarkerOptimal
threshold (%)
Number of patientsProportion with
low biomarker
expression and PD
Proportion with
high biomarker
expression and PD
Fisher’s exact
P value
In analysisLow expressionHigh expression
IPI
  MHC class I304214281.000.640.02
  MHC class II50424110.761.000.99
NIVO
  MHC class I305016340.440.320.53
  MHC class II15035150.460.130.05