Table 2 Disease progression according to defined biomarker thresholds in CheckMate 069.

NPV, negative predictive value; PPV, positive predictive value.

BiomarkerThreshold (%)Number of patientsProportion
with low
biomarker
expression
and PD
Proportion
with high
biomarker
expression
and PD
Fisher’s
exact
P value
Predictive values
(response* versus
nonresponse)
In analysisLow
expression
High
expression
NPV
(95% exact CI)
PPV
(95% exact CI)
IPI
  MHC class I502612140.920.430.01100%
(74–100%)
21%
(5–51%)
  MHC class II12616100.750.500.2394%
(70–99%)
20%
(3–56%)
NIVO + IPI
  MHC class I506332310.310.290.9941%
(24–59%)
55%
(36–73%)
  MHC class II16344190.360.160.1450%
(35–65%)
74%
(49–91%)

*Defined as complete response or partial response.