Table 2 Pathways and genes up-regulated after RAD001 + BEZ235 treatment as determined by gene expression analysis of whole blood.
PathwayMean FC of
genes in
pathway
P valueUp-regulated
genes*
IFN α/β signaling0.0810−21.8IFI27, IFIT2,
IFIT1, IFIT3,
MX1, OAS3,
ISG15
IFN signaling0.0410−36.7IFI27, IFIT2,
IFIT1, IFIT3,
MX1, OAS3,
HERC5, ISG15
Cytokine
signaling in
immune
system
0.0210−43.5IFI27, IFIT2,
IFIT1, IFIT3,
MX1, OAS3,
HERC5, ISG15

*Listed up-regulated genes are those determined to be outliers by the Tukey method of outlier detection.