Table 2 Numbers of differentially expressed genes before and after adjustment for parasite load.

Number of genes associated with severity category or laboratory marker of severity before and after adjustment for parasite load (% of number in unadjusted analysis where applicable). SM, severe malaria; UM, uncomplicated malaria.

Human genesParasite genes
n*UnadjustedLog parasite densityLog PfHRP2n*UnadjustedLog parasite densityLog PfHRP2
SM versus UM43907914 (101%)13 (1.4%)41516562 (109%)329 (64%)
BCS43738491 (67%)12 (1.6%)41445340 (76%)148 (33%)
Lactate401012526 (52%)51 (5.0%)38100109 (109%)47 (47%)
Platelets4317866 (37%)46 (25%)4111 (100%)1 (100%)
Hemoglobin430004165 (83%)4 (67%)

*Only subjects with complete data for every parameter are included.