Table 3 Parasite genes correlated with human gene coexpression modules after adjustment for parasite load.

“+/−” indicates the number of parasite genes positively/negatively correlated with each human module eigengene value. All “top genes” in the table are positively correlated with the module eigengene value. RTP4, receptor transporter protein 4; TNRC6B, trinucleotide repeat containing 6B; ATPase, adenosine triphosphatase; PPIB, peptidylprolyl isomerase B.

Human moduleCorrelated parasite genes after adjustment for parasite load
Hub geneTop GO termn (+/−)Top genesFDR PTop GO termsP
RTP4GO:0034340 response to type 1 IFN2 (2/0)PF3D7_0827500 (apicoplast ribosomal protein L21 precursor)0.014GO:0006412 translation0.018
PF3D7_0111800 (eukaryotic translation initiation factor 4E)0.035
TNRC6BGO:0016569 chromatin modification97 (29/68)PF3D7_1119200 (unknown function)0.00012GO:0008380 RNA splicing4.15 × 10−6
PF3D7_1309100 (60S ribosomal protein L24)0.00027GO:0006396 RNA processing3.88 × 10−5
PF3D7_0825500 (protein KRI1)0.00036
HSPH1GO:0006457 protein folding21 (17/4)PF3D7_0933100 (unknown function)0.0071GO:0000338 protein deneddylation0.0038
PF3D7_1118400 (haloacid dehalogenase-like hydrolase)0.0079
PF3D7_0521800 (ATPase family gene 1-like ATPase)0.01
MMP8GO:0009617 response to bacterium18 (16/2)PF3D7_1356200 (mitochondrial import inner membrane translocase subunit TIM23)0.0045GO:0019219 regulation of nucleobase-containing compound metabolic process0.0065
PF3D7_1119100 (transfer RNA m(1)G methyltransferase)0.0071
PF3D7_0823100 (RWD domain–containing protein)0.0073
PPIBGO:0034976 response to endoplasmic reticulum stress24 (24/0)PF3D7_1420300 (DNL-type zinc finger protein)0.0022GO:0006364 rRNA processing0.0058
PF3D7_0821200 (unknown function)0.0057
PF3D7_1119200 (unknown function)0.0057
RPL24GO:0006614 signal recognition particle-dependent cotranslational protein targeting to membrane93 (78/15)PF3D7_0530600 (XAP-5 DNA binding protein)5.3 × 10−6GO:0006396 RNA processing6.92 × 10−4
PF3D7_1309100 (60S ribosomal protein L24)5.3 × 10−6GO:0008380 RNA splicing1.10 × 10−3
PF3D7_0821200 (unknown function)3.3 × 10−5