Table 1 Uni- and multivariable analysis on PFS and OS in 177 patients with MF in the discovery set.

Treatments used before first evidence of progression, death, or censoring. Phototherapy includes PUVA (psoralen + ultraviolet A) and UVB therapy. Radiation therapy includes electron-beam therapy and brachytherapy. Systemic treatments include interferon-α, oral bexarotene, folate inhibitors, systemic histone deacetylase inhibitors, and monoclonal antibodies. The multivariable model was stratified on LDH levels and the use of systemic treatments. CI, confidence interval.

Discovery set (n = 177)
Progression-free survivalOverall survival
UnivariableMultivariableUnivariableMultivariable
HR95% CIPHR95% CIPHR95% CIPHR95% CIP
Tumor clone frequency>15%2.11.3–3.50.0022.51.4–4.70.003
>25%4.02.4–6.8<0.0013.31.9–5.9<0.0014.82.6–9.0<0.0015.12.5–10<0.001
>35%4.62.6–8.1<0.0015.22.7–10<0.001
LDH levelsElevated versus normal2.31.2–4.30.0083.21.6–6.50.001
Large-cell transformationPresence3.41.8–6.4<0.0011.80.9–3.70.13.31.6–7.00.0011.30.5–3.00.6
Age>60 years2.21.3–3.70.0022.31.3–4.00.0033.41.7–6.70.00053.51.7–7.4<0.001
TreatmentsPhototherapy0.90.5–1.50.70.80.4–1.50.5
Radiation therapy1.91.1–3.40.021.40.7–2.50.31.80.9–3.80.1
Systemic treatments3.42.1–5.5<0.0013.92.1–7.1<0.001
PCRClonal pattern1.50.7–3.40.31.00.5–4.20.4
GenderMale versus female1.50.9–2.50.11.20.7–2.40.5
FolliculotropismPresence1.50.9–2.50.11.20.6–2.30.6