Table 3 Pharmacokinetics of NS-065/NCNP-01.
ParameterInitial doseFinal dose
Cohort 1 (n = 3)Cohort 2 (n = 3)Cohort 3 (n = 4)Cohort 1 (n = 3)Cohort 2 (n = 3)Cohort 3 (n = 4)
Cmax (ng/ml)6040 ± 30021,800 ± 4,40070,200 ± 44,9005640 ± 244019,500 ± 1,40072,800 ± 26,400
Tmax (hours)1.00 ± 0.000.833 ± 0.2890.750 ± 0.2890.833 ± 0.2890.667 ± 0.2890.875 ± 0.250
AUC0-t (ng hour/ml)8410 ± 131028,700 ± 3,90098,900 ± 54,1008410 ± 352027,700 ± 8,800115,000 ± 56,000
T1/2 (hours)1.66 ± 0.171.65 ± 0.201.84 ± 0.761.78 ± 0.051.52 ± 0.061.73 ± 0.76
Vd (ml/kg)183 ± 14200 ± 27264 ± 68232 ± 79219 ± 24224 ± 41
CLtot (ml/hour per kg)149 ± 21175 ± 26239 ± 97162 ± 58190 ± 52203 ± 87