Table 1 Clinical data.

Patient identification number, age, tumor histologic type (ovarian, epithelial ovarian cancer; peritoneal, primary peritoneal serous carcinoma), FIGO stage, number of prior chemotherapy lines (chemos), number of prior recurrences, protocol cohort, combination therapy with vaccine (bev, bevacizumab; cy/bev, cyclophosphamide and bevacizumab), total number of vaccine doses received, clinical response, remission inversion status after vaccination, vaccine, tumor, and new antigen immune response are reported. Vx, vaccine; PD, progressive disease; SD, stable disease; PR, partial response; Y, yes; N, no; NR, nonresponder; R, responder.

IDAgeTypeStageNo. of
prior
chemos
No. of prior
recurrences
CohortTreatmentNumber
of
vaccines
received
Clinical
response
EOS
Clinical
response
Remission
inversion
Last
relapse—
free time/
current
relapse—
free time
ratios
Vaccine immune
response
Tumor
immune
response
Neoantigen immune
response
LineagePrePost
CTE-002048OvarianIIIC421Vx3PDPDN0.23
CTE-000146OvarianIV521Vx28SDSDY1.64NRR
CTE-000249OvarianIV411Vx7SDSDY7.64RR
CTE-000363OvarianIIC941Vx5PDSDN0.96NR
CTE-000459PeritonealIIIC311Vx6SDPDN0.45NRNR
CTE-000560OvarianIV512Vx/Bev10SDPRY4.95NRR
CTE-000663OvarianIV632Vx/Bev4PDPDN0.49
CTE-002159OvarianIIIC412Vx/Bev5PDPDN0.68NR
CTE-002254OvarianIV632Vx/Bev2SDSDN0.78
CTE-000760OvarianIIIC212Vx/Bev18SDSDY1.18NRR
CTE-000854OvarianIIIC312Vx/Bev5PDPDN0.69RCD4NRSEMA3GP>A
CTE-000972PeritonealIIIC512Vx/Bev8PDPDN0.78NRR
CTE-001061PeritonealIIIC522Vx/Bev10SDSDY1.20RRTRIM26G>W,
CHD3L>V,
EBF4I>S,
DCHS1P>L
TRIM26G>W,
CHD3L>V,
DCHS1P>L
CTE-001163OvarianIIIC412Vx/Bev5PDPDN0.21NRNRSEPT9R>H
CTE-001268OvarianIIIC512Vx/Bev16SDSDN0.52NR
CTE-001349OvarianIIIB213Vx/Bev/Cy15SDSDY1.06RRHHATL>FHHATL>F
CTE-001443PeritonealIIIC423Vx/Bev/Cy8PDPDN0.35NR
CTE-001547OvarianIIIC433Vx/Bev/Cy9PDPDN0.62RNRZCCHC11P>H,
OR2T3C>Y,
TNRC6AP>Q
ZCCHC11P>H,
TNRC6AP>Q
CTE-001667OvarianIIIC213Vx/Bev/Cy5SDSDY1.10RR
CTE-002344OvarianIIIC423Vx/Bev/Cy10SDSDY4.37RCD4+CD8
CTE-002453OvarianIV313Vx/Bev/Cy11SDPDN0.78RCD4
CTE-001738OvarianIIIC323Vx/Bev/Cy10SDPRY1.49RCD4+CD8
CTE-002555OvarianIIIC333Vx/Bev/Cy10SDSDY2.09RCD4+CD8
CTE-001865OvarianIIIC533Vx/Bev/Cy10SDSDN0.33NR
CTE-001961OvarianIIIC423Vx/Bev/Cy5SDSDY1.61RRODZ3A>VP2RX5A>G,
PLK3S>L,
MUC4H>D,
DNAAF2S>L,
KDM5CE>K,
ODZ3A>V