Table 1 Appearance of disease after bronchoscopic instillation of Mtb into rabbits.

Numbers in parentheses represent time (in weeks) after infection. The terms small, some, large, and huge represent the diameter of disease lesions, ≤0.5, 0.5 to 1.0, 1.0 to 2, and ≥2 cm, respectively. Mycobacterium tuberculosis, Mtb; CFU, colony-forming factor; CT, computed tomography.

Concentration
of Mtb H37Rv
strain (CFU/ml)
Volume (in
milliliters) per
instillation per
rabbit
First CT scan
result
(weeks after
infection)
Second CT
scan or clinical
result (weeks
after infection)
5 × 1041.2No sign of
disease (3)
No disease (8)
1.2Small
consolidation (3)
Clear (8)
1.2Small
consolidation (3)
Clear (8)
5 × 1050.2Some
consolidation (3)
Clear (6)
0.4Some
consolidation (3)
Clear (6)
0.6Some
consolidation (3)
Clear (6)
1.2Some
consolidation (3)
Clear (8)
1.2Some
consolidation (3)
Two cavities (6)
1.2Some
consolidation (3)
Two cities (7)
5 × 1060.2Some
consolidation (3)
Two cavities (6)
0.4Large
consolidation (3)
Some diffusion (8)
0.6Large
consolidation (3)
One cavity (3)
1.2Huge
consolidation (3)
Sacrificed (3)
1.2Huge
consolidation (3)
Sacrificed (3)
1.2Huge
consolidation (3)
Sacrificed (3)
5 × 1070.15Large
consolidation (1)
Three cavities (4)
0.30Large
consolidation (1)
One cavity (4)
5 × 1080.15Large
consolidation (1)
Two cavities (4)