Rifampin (sample size) | n/N | Rifapentine (sample size) | n/N | |

Plasma | 38/8 | 49/11 | ||

CL (liter/hour per kg) | 0.175 (3) | 0.087 (26) | ||

V (liter/kg) | 0.54 (5) | 0.67 (11) | ||

Residual error of plasma, CV % | 34 (5) | 23 (15) | ||

IIV (CL), CV % | 42 (17) | 65 (30) | ||

IIV (V), CV % | — | 30 (42) | ||

Correlation CL-V | — | 0.59 (27) | ||

Uninvolved lung | 15/5 | 42/11 | ||

Ratio of uninvolved lung/plasma | 0.78 (12) | 0.71 (12) | ||

Rate constant of plasma to uninvolved lung (1/hour) | 1.29 (27) | 10 FIX | ||

Residual variability of uninvolved lung, CV % | 22 (41) | 33 (38) | ||

Cellular lesion | 20/5 | 19/6 | ||

Ratio of cellular lesion/plasma | 1.12 (5) | 1.1 (14) | ||

Rate constant of plasma to cellular lesion (1/hour) | 0.59 (19) | 1.86 (33) | ||

Residual variability of cellular lesion, CV % | 19 (30) | 27 (25) | ||

Tissue surrounding lesion | 12/5 | 15/6 | ||

Ratio of tissue surrounding lesion/plasma | 1.01 (16) | 1.05 | ||

Rate constant of plasma to tissue surrounding lesion (1/hour) | 0.74 (138) | 0.83 | ||

Residual variability of tissue surrounding lesion, CV % | 22 (55) | 29 | ||

Cavity caseum | 9/3 | 13/4 | ||

Ratio of cavity caseum/plasma | 1.11 (21) | 0.25 (21) | ||

Rate constant of plasma to cavity caseum (1/hour) | 0.086 (40) | 234 (40) | ||

Residual variability of cavity caseum, CV % | 57 (5) | 60 (31) | ||

Cavity wall | 7/2 | 16/4 | ||

Ratio of cavity wall/plasma | 0.98 (8) | 1.01 (8) | ||

Rate constant of plasma to cavity wall (1/hour) | 0.37 (13) | 0.63 (4) | ||

Residual variability of cavity wall, CV % | 26 (42) | 15 (5) |