Table 2 Rifampin and rifapentine penetration into rabbit tubercular lesions and healthy lung tissue.

n, number of samples; N, number of animals. FIX, parameter was fixed; 1/hour, per hour; CL, clearance; V, volume of distribution; CV, coefficient of variance.

Rifampin (sample size)n/NRifapentine (sample size)n/N
Plasma38/849/11
CL (liter/hour per kg)0.175 (3)0.087 (26)
V (liter/kg)0.54 (5)0.67 (11)
Residual error of plasma, CV %34 (5)23 (15)
IIV (CL), CV %42 (17)65 (30)
IIV (V), CV %30 (42)
Correlation CL-V0.59 (27)
Uninvolved lung15/542/11
Ratio of uninvolved lung/plasma 0.78 (12)0.71 (12)
Rate constant of plasma to
uninvolved lung (1/hour)
1.29 (27)10 FIX
Residual variability of
uninvolved lung, CV %
22 (41)33 (38)
Cellular lesion20/519/6
Ratio of cellular lesion/plasma1.12 (5)1.1 (14)
Rate constant of plasma to
cellular lesion (1/hour)
0.59 (19)1.86 (33)
Residual variability of cellular
lesion, CV %
19 (30)27 (25)
Tissue surrounding lesion12/515/6
Ratio of tissue surrounding
lesion/plasma
1.01 (16)1.05
Rate constant of plasma to
tissue surrounding lesion
(1/hour)
0.74 (138)0.83
Residual variability of tissue
surrounding lesion, CV %
22 (55)29
Cavity caseum9/313/4
Ratio of cavity caseum/plasma1.11 (21)0.25 (21)
Rate constant of plasma to
cavity caseum (1/hour)
0.086 (40)234 (40)
Residual variability of cavity
caseum, CV %
57 (5)60 (31)
Cavity wall7/216/4
Ratio of cavity wall/plasma0.98 (8)1.01 (8)
Rate constant of plasma to
cavity wall (1/hour)
0.37 (13)0.63 (4)
Residual variability of cavity
wall, CV %
26 (42)15 (5)