Each animal trial was performed independently in five pigs using the IVC occlusion intervention. An additional case was performed with animal 5 at a different operating speed (42K = 42,000 rpm) to demonstrate parity at multiple speeds. ΔP is the pressure difference between the aortic and left ventricular pressure, of which all animals had a minimum gradient of ~0 mmHg. Mean arterial pressure (MAP) is shown at baseline and during peak intervention. bpm, beats per minute.
Animal 1 | Animal 2 | Animal 3 | Animal 4 | Animal 5 | Animal 5 (42K) | |
Mass (kg) | 77.3 | 70.0 | 79.4 | 71.4 | 68.0 | 68.0 |
Heart rate (bpm) | 125 | 110 | 97 | 116 | 129 | 110 |
MAP baseline (mmHg) | 104.0 | 65.3 | 88.1 | 83.3 | 98.2 | 98.6 |
MAP occlusion (mmHg) | 71.8 | 38.2 | 71.7 | 62.1 | 60.5 | 79.5 |
ΔP max (mean) (mmHg) | 109.0 (41.9) | 70.2 (21.9) | 105.4 (45.7) | 93.4 (33.7) | 81.3 (32.1) | 90.9 (38.3) |
LVEDP max/min (mean) (mmHg) | 19.5/4.4 (15.8) | 9.4/3.1 (8.4) | 7.1/4.7 (6.0) | 13.8/10.1 (12.3) | 23.5/15 (22) | 23.8/9.0 (19.7) |
LVEDP data points | 45 | 62 | 35 | 33 | 94 | 32 |
Mean absolute error (mmHg) | 0.92 | 0.31 | 1.58 | 0.98 | 1.00 | 0.84 |