Table 1 In vivo lineage-traced fibrogenic MSC populations shown to participate in tissue fibrosis.

MSC, mesenchymal stromal cell; Lrat, lecithin-retinol acyltransferase; EN-1, engrailed 1.

Organ/tissueLineage tracing markerMSC populations labeledAdult mesenchymal tissue
contribution in vivo
References
LungFoxD1Pericyte-like MPCMyofibroblast(59)
NG2PericytePericyte(60)
AdrpLipofibroblastMyofibroblast(61)
PDGFRαFibroblastFibroblast(60)
Skeletal musclePDGFRαPericyte-like MPCMyofibroblast, adipocyte(20, 25)
ADAM12Pericyte-like MPCMyofibroblast(23)
LiverLratPericyte-like MPCMyofibroblast(45)
KidneyFoxD1Pericyte-like MPC, pericytes, pertibular fibroblastsMyofibroblast, pericyte(33)
Gli1Pericyte-like MPCMyofibroblast, pericyte(34)
Bone marrowLepRPericyte-like MPCMyofibroblast, osteocyte,
chondrocyte, adipocyte
(1012)
Gli1Pericyte-like MPC, endosteal
MPCs
Myofibroblast(18)
SkinADAM12Pericyte-like MPCMyofibroblast(23)
EN-1FibroblastMyofibroblast(68)
Dlk1Fibroblast/MPCMyofibroblast, adipocyte(69)