Table 2 Allele frequencies and association statistics for LRRK2 nonsynonymous variants in imputed data sets.

CI, confidence interval.

MAFCD (%)MAFPD (%)MAFCTRL(%)* CD versus control associationPD versus control association
OR (95% CI) POR (95% CI)P
N551K variant
Ashkenazi Jewish6.87.79.80.67 (0.57–0.79)1.4 × 10−60.77 (0.67–0.90)3.9 × 10−4
Non-Jewish6.06.26.90.89 (0.79–1.0)5.1 × 10−20.87 (0.77–1.0)4.4 × 10−2
R1398H variant
Ashkenazi Jewish6.87.69.10.71 (0.60–0.84)5.0 × 10−50.84 (0.72–0.98)1.6 × 10−2
Non-Jewish6.16.26.90.88 (0.78–0.99)4.0 × 10−20.88 (0.77–1.0)5.6 × 10−2
N2081D variant
Ashkenazi Jewish8.05.95.41.7 (1.4–2.0)4.3 × 10−81.1 (1.0–1.4)3.6 × 10−2
Non-Jewish2.92.41.81.6 (1.3–2.0)2.1 × 10−61.3 (1.0–1.6)1.7 × 10−2

*Combined control MAF. Each healthy control was randomly assigned to only one disease association analysis to ensure independence. P values calculated using logistic regression.