Table 1 List of the top variants that reached genome-wide significance in meta-analysis.

SNP, single nucleotide polymorphism; MAFCD, minor allele frequency in CD cases; MAFCTRL, MAF in controls; OR, odds ratio. P values for discovery and replication cohorts calculated using χ2 test. Meta-analysis performed using METAL default method. Chr, chromosome.

Ref SNP IDChrCoordinateGeneSubstitutionDiscovery (N = 1477 cases,
2614 controls)
Replication (N = 589 cases,
1019 controls)
Meta-
analysis
MAFCD
(%)
MAFCTRL
(%)
PORMAFCD
(%)
MAFCTRL
(%)
PORP
rs11209026167705958IL23RR381Q3.228.036.79 × 10−180.383.158.053.36 × 10−80.371.38 × 10−24
rs1395188631240499594SLC2A13S6N8.104.842.68 × 10−91.737.655.369.58 × 10−31.461.39 × 10−10
rs73087201240657700LRRK2N551K6.649.857.06 × 10−70.657.7810.451.27 × 10−20.723.28 × 10−8
rs339958831240740686LRRK2N2081D8.134.862.56 × 10−91.737.405.614.40 × 10−21.349.51 × 10−10
rs1413267331650138853HEATR3R642S2.781.033.16 × 10−92.741.870.932.29 × 10−22.024.76 × 10−10
rs20668421650744624NOD2P268S32.4223.032.25 × 10−201.6032.4420.074.21 × 10−151.913.31 × 10−33
rs20668441650745926NOD2R702W3.631.881.19 × 10−61.973.822.114.25 × 10−31.841.76 × 10−8
rs1048954471650750842NOD2M863V4.061.051.57 × 10−193.983.571.081.15 × 10−63.391.28 × 10−24
rs20668451650756540NOD2G908R8.734.215.14 × 10−172.187.993.294.12 × 10−92.551.52 × 10−24
rs20668471650763781NOD2L1007fs8.332.756.27 × 10−303.217.472.407.09 × 10−123.283.43 × 10−40