Table 3 Subphenotypic values by LRRK2 N2081D and R1398H genotype in pooled Ashkenazi Jewish and non-Jewish CD cohorts.

Similar results were found for the N551K variant (in strong LD with R1398H; r2 = 0.81). P values were calculated using simple linear regression. SD, standard deviation; N, group sample size; ns, not significant.

N2081D genotypeAge of CD onset (SD)
[N]
Disease location in
ileum [N]
AA26.5 (14.0) [5601]80.5% [5311]
GA24.6 (13.1) [482]86.1% [453]
GG20.8 (9.0) [12]90.9% [11]
P = 0.002P = 0.01
R1398H genotype
GG26.3 (13.9) [5365]81.1%[5095]
GA26.4 (14.1) [701]80.7% [652]
AA27.2 (19.4) [29]71.4% [28]
nsns