Table 2 Select FDA-approved drugs with repurposing potential for mechano-based therapeutic interventions.
DrugTrade nameCompanyDiseaseTargetReference
PirfenidoneEsbrietGenentechIdiopathic lung fibrosisTGFβ signaling(36)
NintedanibOfevBoehringer IngelheimIdiopathic lung fibrosisVEGF, FGF,
and PDGF receptors
(40)
StatinsMultipleMultipleCardiovascular diseaseRho, YAP/TAZ(98, 125)
Verteporfin injectionVisudyneNovartisMacular degenerationYAP(126)
BortezomibVelcadeTakedaMultiple myelomaNF-κB(138, 139)
IxazomibNilaroTakedaMultiple myelomaNF-κB(139)
CarfilzomibKyprolisAmgenMultiple myelomaNF-κB(138, 139)
VemurafenibZelborafGenentechMelanomaB-Raf(146)
DabrafenibTafinlarNovartisMelanomaB-Raf(145, 146)
CobimetinibCotellicGenentechMelanomaMEK(146)
TrametinibMekinistNovartisMelanomaMEK(145, 146)