Table 1. Summary of AA signature mutations in HCCs.
Geographic
origin
Number
of HCCs
Median
(all SBS
mutations/
Mb)
HCCs with
AA signature
Weighted counts* of AA signature
SBS mutations among HCCs with the signature
Number of
HCCs with
nonsilent AA
signature
SBS
mutations in
known
drivers
P value
for difference
from Taiwan
in proportion
of HCCs with
the AA signature
(Fisher’s exact
test)
SBS
mutations/Mb
Number of
nonsilent SBS
mutations
Number of
nonsilent SBS
mutations in
known driver
Number
of HCCs
Proportion
of HCCs
MedianMeanMedianMeanMedianMean
New data, this paper
  Taiwan983.33760.782.264.94101.6223.32.193.9457
Previously published data
  China891.94420.470.291.075.832.60.060.5092.0 × 10−5
  Southeast Asia
(excluding
Vietnam)
95.7450.562.923.0762.343.10.080.9720.22
  Vietnam263.1050.193.423.71125.4126.81.612.3657.3 × 10−8
  Korea2311.78290.131.001.2941.456.21.061.18192.1 × 10−30
  Japan4774.82130.0270.600.948.213.50.040.2332.2 × 10−60
  North
America
2092.36100.0480.992.6032.984.40.531.5152.6 × 10−40
  Europe2301.6740.0170.359.7215.216.00.340.3507.3 × 10−49
  Mayo Clinic892.94190.211.302.2739.277.00.891.46116.0 × 10−15
  No
information
302.7950.170.460.5713.917.10.300.7622.6 × 10−9
  Total
non-Taiwan
1400

*We ascribe the AA signature to a proportion of each SBS as described in Materials and Methods. Because the AA signature is dominated by A:T>T:A SBS, when the activities of other signatures with these SBS mutations are low or absent, this approximates the number of A:T>T:A SBS mutations. The weighted counts are the sums of the proportions of SBS mutations ascribed to the AA signature.

P = 7.1 × 10−7, for all Southeast Asia, including Vietnam.

‡Includes 10 additional TCGA HCCs: 1 Russia, 5 Brazil, 4 South Korea; 1 Brazil HCC has the AA signature.