Table 1. PK parameters of ERY974 in cynomolgus monkeys after a single intravenous infusion of ERY974.

Animals that developed anti-drug antibodies (ADA) were excluded from the analysis. The mean of three animals is shown. MRT, mean residence time.

DoseSext1/2AUCinfCLtotalVd,ssCmaxMRT
(day)(ng/day
per ml)
(ml/day
per kg)
(ml/kg)(ng/ml)(day)
0.1 μg/kgMale*3.874.422.81111.864.88
Female2.893.7526.81041.673.89
1 μg/kgMale*3.7237.826.511616.94.38
Female*3.6234.629.312315.94.29
10 μg/kgMale3.6836627.31092173.97
Female*3.5237926.61081894.08

*Data from one ADA-positive animal were excluded.

†Data from two ADA-positive animals were excluded.