Table 1. Toxicological results and organ weights.
ParametersControl (n = 5)3600 μg/kg (n = 5)Historical control values*
White blood cells (×103/μl)9.9 ± 1.17.8 ± 1.09.6 ± 3.0
Red blood cells (×106/μl)8.3 ± 0.28.1 ± 0.38.5 ± 0.6
Hemoglobin (g/dl)15.1 ± 0.414.8 ± 0.315.9 ± 0.9
Blood urea nitrogen (mg/dl)18.0 ± 2.217.8 ± 2.418 ± 3.2
Creatinine (mg/dl)0.40 ± 0.010.42 ± 0.030.46 ± 0.12
Albumin (g/dl)3.54 ± 0.063.62 ± 0.083.4 ± 0.17
Total bilirubin (mg/dl)0.11 ± 0.010.10 ± 0.010.12 ± 0.024
Alanine aminotransferase (U/liter)43.6 ± 8.138.6 ± 2.446 ± 15.3
Total protein (g/dl)6.18 ± 0.166.28 ± 0.116.2 ± 0.41
Body weight (g)268.4 ± 4.2271.4 ± 5.9
Organ–to–body weight ratio
  Brain0.69 ± 0.040.71 ± 0.02
  Adrenal glands0.026 ± 0.0140.020 ± 0.004
  Heart0.41 ± 0.040.41 ± 0.02
  Kidneys0.73 ± 0.050.70 ± 0.04
  Liver3.04 ± 0.093.04 ± 0.11
  Spleen0.25 ± 0.010.25 ± 0.02
  Testes1.36 ± 0.041.29 ± 0.06
  Thyroid/parathyroid0.0062 ± 0.00110.0058 ± 0.0011

*The historical control value was obtained from the analysis of ~1750 individual normal rats.

Body weight and organ weight were measured on day 8.