Table 2. AUC calculations of ELISA results for PDAC at different stages, bootstrapped (1000 repetitions) at 95% CIs.
PDAC versus healthy controlsCA19-9 (≥55)THBS2CA19-9 (≥55) + THBS2
nAUC95% CIAUC95% CIAUC95% CIP
Validation phase 2a
All stages81/800.8460.810.890.8420.800.900.9560.930.980.0003
Stage I/II58/800.8450.800.890.8320.780.890.9460.920.980.0067
Stage I8/800.9380.831.000.8390.690.980.9770.931.000.5038
Stage II50/800.8300.780.880.8300.780.890.9400.910.980.0080
Stage III/IV23/800.8460.790.900.8420.780.900.9560.920.990.0003
Validation phase 2b
All stages197/1400.8810.860.910.8750.850.900.9700.960.98<0.0001
Stage I/II88/1400.8340.790.870.8870.850.920.9600.940.98<0.0001
Stage I10/1400.7930.660.930.8960.830.970.9520.920.990.0574
Stage II78/1400.8390.800.880.8850.850.920.9610.940.98<0.0001
Stage III/IV109/1400.9190.890.950.8660.830.900.9800.970.990.0028