Table 1. Characteristics of P. falciparum parasitemia in CHMI subjects in vivo.
NF54NF135.C10NF166.C8NF54 versus
NF135.C10
NF54 versus
NF166.C8
NF135.C10 versus
NF166.C8
CHMI-a
  No. of subjects per group555
  First detection of
parasitemia by qPCR
(days after infection)
7.5
(6.5 to 8.5)
6.5
(6.5 to 6.5)
6.5
(6.5 to 6.5)
1.0
(0.1 to 1.9)*
1.0
(0.1 to 1.9)*
  Peak parasitemia
(log10 parasites/ml)
    First wave¤1.96
(1.23 to 3.52)
4.28
(3.41 to 4.79)
3.89
(2.83 to 4.79)
−2.32
(−3.69 to −0.96)**
−1.93
(−3.30 to −0.56)**
0.39
(−0.97 to 1.76)
    Overall4.43
(3.84 to 5.17)
4.64
(4.24 to 5.19)
4.22
(2.83 to 4.79)
−0.20
(−1.19 to 0.78)
0.21
(−0.77 to 1.20)
0.42
(−0.56 to 1.40)
CHMI-b
  No. of subjects
per group
44
  First detection of
parasitemia by qPCR
(days after infection)
6.5
(6.5 to 6.5)
6.5
(6.5 to 6.5)
  Peak parasitemia
(log10 parasites/ml)
    First wave¤3.61
(2.59 to 4.19)
4.09
(3.77 to 4.34)
−0.48
(−1.63 to 0.66)
    Overall3.94
(3.82 to 4.19)
4.09
(3.77 to 4.34)
−0.15
(−0.62 to 0.32)
All CHMI studies
  No. of subjects
per group§
902214
  First detection of
parasitemia by qPCR
(days after infection)§
7.2
(6.3 to 10.6)
6.7
(6.5 to 7.0)
6.5
(6.5 to 6.5)
0.52
(−0.004 to 1.0)
0.70
(0.070 to 1.3)*
0.18
(−0.57 to 0.93)
  Peak parasitemia
(log10 parasites/ml)
    First wave¤§2.72
(1.00 to 4.67)
3.67
(2.59 to 4.79)
3.78
(2.78 to 4.79)
−0.95
(−1.41 to −0.49)***
−1.06
(−1.61 to −0.51)***
−0.11
(−0.79 to 0.58)
    Overall◊||4.28
(3.13 to 5.17)
4.72
(3.35 to 5.84)
4.22
(2.83 to 4.97)
−0.44
(−0.86 to −0.009)*
0.065
(−0.58 to 0.71)
0.50
(−0.23 to 1.23)

†Data represent mean per group (range).

‡Data represent mean differences between groups (95% CI of difference). Boldface indicates statistical significance (*P < 0.05, **P < 0.01, and ***P < 0.001 by one-way ANOVA/Tukey’s post hoc test).

§Data included from all 18 comparable CHMI studies performed at our center using either thick smear microscopy or qPCR as an end point (table S3).

||Data included from only those 10 CHMI studies performed at our center in which subjects were treated upon positive standardized thick blood smear (n = 56 NF54-infected, n = 13 NF135.C10-infected, and n = 5 NF166-infected subjects, respectively).

¤Peak height of parasitemia during the first wave to emerge from the liver, defined as the highest parasite density measured by qPCR per subject between day 6.5 and 8.0 after infection; data represent geometric mean (range) per group.

◊Peak height of parasitemia per subject at any time after infection (generally at start of treatment); data represent geometric mean (range) per group.