Table 3. Neutralizing potency of different VP4 or VP7 mAbs against escape variants.
Parental
virus/variants
Mutation siteVP4 Neutralizing
mAbs*
#41#33#47
Wa0.64.91.2
Wa41v-1-1Amino acid 392 (A→E)>625.0>625.01.2
Wa41v-2-1Amino acid 123 (G→D)0.64.9156.3
VP7 Neutralizing
mAbs*
#27#57#46
DxRRV0.62.42.4
DRV57v-30-1Amino acid 126 (D→N)0.6>625.02.4
DRV27v31-1Amino acid 151 (D→H)19.50.678.1

*Minimum neutralizing concentration (nanograms per milliliter).