Table 1. Summary of the protein specificity of RV-specific human recombinant mAbs. CF, clonal family; S, singleton; ND, VP5* or VP8* specificity not determined.
mAb no.Subject IDViral protein
specificity
Minimum
concentration
for TLP binding
(ng/ml)
G serotype or
P genotype
binding activity
In vitro
neutralization
activity
Clonal family or
singleton
2001VP4VP5*5.00P[4] and P[8]YesCF
30002VP5*5.00P[1], P[4], P[6], P[7], and P[8]YesCF
33002VP5*0.50P[1], P[3], P[4], P[6], P[7], and P[8]YesCF
41003VP5*0.01P[1], P[3], P[4], P[6], P[7], and P[8]YesCF
4001VP8*0.50P[4] and P[8]NoCF
6*004VP8*5.00P[4] and P[8]NoCF
8004VP8*0.05P[4] and P[8]NoCF
9004VP8*0.01P[4] and P[8]YesCF
11004VP8*0.01P[4] and P[8]NoCF
12005VP8*0.05P[4] and P[8]NoCF
13005VP8*5.00P[8]NoCF
14005VP8*0.50P[4] and P[8]NoCF
15005VP8*0.50P[4] and P[8]NoS
16005VP8*0.01P[4] and P[8]NoCF
18005VP8*0.05P[4], P[6], and P[8]NoCF
19005VP8*0.05P[4] and P[8]YesCF
20005VP8*0.01P[4] and P[8]NoS
21005VP8*0.50P[4] and P[8]NoS
23005VP8*50.00P[4] and P[8]NoS
29002VP8*0.05P[8]NoS
31002VP8*0.50P[4] and P[8]NoCF
35002VP8*0.50P[1], P[4], P[7], and P[8]NoS
43005VP8*0.50P[8]NoS
44002VP8*0.50P[4] and P[8]NoCF
55001VP8*500.00P[4], P[6], and P[8]NoCF
60002VP8*0.50P[1], P[3], P[6], and P[8]NoCF
47002VP8*0.50P[4] and P[8]YesS
62003ND5.00P[4] and P[8]NoCF
22005VP75.00G1NoS
270020.01G1, G5, and G9YesCF
460020.50G1YesS
570020.50G1, G2, G3, G4, and G5YesS
10*004VP60.5G1, G2, G3, G4, G5, and G6NoCF

*IgA. All other mAbs were expressed as IgG.

†Reacts with TLPs and DLPs. All other mAbs react only with TLPs.