Table 1. AZD4785 PK measurements from liver at the end of the LXFA 983 studies.
ModelStudyDose
concentration
Length of study
(days)
Liver PK
(μg/g)
MeanSD
LXFA
983
P198U/
Q610
250 mpk/week27215.232.8
LXFA
983
P198U/
Q610
250 mpk/week41239.029.8
LXFA
983
P198U3/
Q738
250 mpk/week35407.853.1
LXFA
983
P198U3/
Q738
125 mpk/week35344.449.1