Table 2. Statistical analyses of EV markers for training and prospective cohorts.

Ninety-five percent CIs are indicated in parentheses. NA, not applicable.

Biomarker(s)nCutoffAUCTraining cohort (n = 32)Prospective cohort (n = 43)
Sensitivity (%)Specificity (%)Accuracy (%)Sensitivity (%)Specificity (%)Accuracy (%)
EGFR10.15
(0.01–0.24)
0.90
(0.79–1)
731008159
(36–79)
76
(53–92)
67
(51–81)
EPCAM10.28
(0.01–0.34)
0.88
(0.77–0.99)
731008145
(24–68)
95
(76–100)
70
(54–83)
HER210.13
(0.03–0.32)
0.72
(0.55–0.89)
59906959
(36–79)
85
(64–97)
72
(56–85)
MUC110.34
(0.02–0.53)
0.66
(0.48–0.84)
361005636
(17–59)
90
(70–99)
63
(47–77)
GPC110.04
(0.04–0.68)
0.48
(0.28–0.67)
55605682
(60–95)
52
(30–74)
67
(51–81)
WNT210.18
(0.09–0.48)
0.84
(0.71–0.96)
77908164
(41–83)
76
(53–92)
70
(54–83)
GRP9410.10
(0.02–0.46)
0.73
(0.55–0.90)
73707255
(32–76)
71
(48–89)
63
(47–77)
B7-H310.19
(0.02–0.23)
0.75
(0.58–0.93)
5010059NANANA
EGFR + EPCAM + HER2 + MUC140.67
(0.29–0.68)
0.99
(0.97–1)
911009486
(65–97)
86
(64–97)
86
(72–95)
EGFR + EPCAM + GPC1 + WNT240.74
(0.65–0.84)
1.010010010082
(60–95)
90
(70–99)
86
(72–95)
EGFR + EPCAM +
MUC1 + GPC1 +
WNT2
50.87
(0.68–1.00)
1.010010010086
(65–97)
81
(58–95)
84
(69–93)
EGFR + EPCAM + HER2 + MUC1 + GPC1 + WNT260.89
(0.73–1.00)
1.010010010095
(77–100)
81
(58–95)
88
(75–96)