Ninety-five percent CIs are indicated in parentheses. NA, not applicable.
Biomarker(s) | n | Cutoff | AUC | Training cohort (n = 32) | Prospective cohort (n = 43) | ||||
Sensitivity (%) | Specificity (%) | Accuracy (%) | Sensitivity (%) | Specificity (%) | Accuracy (%) | ||||
EGFR | 1 | 0.15 (0.01–0.24) | 0.90 (0.79–1) | 73 | 100 | 81 | 59 (36–79) | 76 (53–92) | 67 (51–81) |
EPCAM | 1 | 0.28 (0.01–0.34) | 0.88 (0.77–0.99) | 73 | 100 | 81 | 45 (24–68) | 95 (76–100) | 70 (54–83) |
HER2 | 1 | 0.13 (0.03–0.32) | 0.72 (0.55–0.89) | 59 | 90 | 69 | 59 (36–79) | 85 (64–97) | 72 (56–85) |
MUC1 | 1 | 0.34 (0.02–0.53) | 0.66 (0.48–0.84) | 36 | 100 | 56 | 36 (17–59) | 90 (70–99) | 63 (47–77) |
GPC1 | 1 | 0.04 (0.04–0.68) | 0.48 (0.28–0.67) | 55 | 60 | 56 | 82 (60–95) | 52 (30–74) | 67 (51–81) |
WNT2 | 1 | 0.18 (0.09–0.48) | 0.84 (0.71–0.96) | 77 | 90 | 81 | 64 (41–83) | 76 (53–92) | 70 (54–83) |
GRP94 | 1 | 0.10 (0.02–0.46) | 0.73 (0.55–0.90) | 73 | 70 | 72 | 55 (32–76) | 71 (48–89) | 63 (47–77) |
B7-H3 | 1 | 0.19 (0.02–0.23) | 0.75 (0.58–0.93) | 50 | 100 | 59 | NA | NA | NA |
EGFR + EPCAM + HER2 + MUC1 | 4 | 0.67 (0.29–0.68) | 0.99 (0.97–1) | 91 | 100 | 94 | 86 (65–97) | 86 (64–97) | 86 (72–95) |
EGFR + EPCAM + GPC1 + WNT2 | 4 | 0.74 (0.65–0.84) | 1.0 | 100 | 100 | 100 | 82 (60–95) | 90 (70–99) | 86 (72–95) |
EGFR + EPCAM + MUC1 + GPC1 + WNT2 | 5 | 0.87 (0.68–1.00) | 1.0 | 100 | 100 | 100 | 86 (65–97) | 81 (58–95) | 84 (69–93) |
EGFR + EPCAM + HER2 + MUC1 + GPC1 + WNT2 | 6 | 0.89 (0.73–1.00) | 1.0 | 100 | 100 | 100 | 95 (77–100) | 81 (58–95) | 88 (75–96) |