Table 2. MMV390048 radical cure (≥24-hour addition) versus prophylactic (3-hour addition) effects in the P. cynomolgi liver-stage assay.

EEF, exoerythrocytic forms.

Approximate time of
MMV390048 addition
Small EEFs
(hypnozoites)
IC50 (μM)*
Large EEFs
(schizonts)
IC50 (μM)*
3 hours (day 0)0.0610.064
24 hours (day 1)2.60.097
72 hours (day 3)5.10.31
96 hours (day 4)7.01.0
120 hours (day 5)>101.5

*Data from three independent biological replicates.