Table 1. Transmission-blocking effects of MMV390048 (2 mg/kg) measured in the mouse-to-mouse transmission model.
Effect on transmission
to the mosquito
vector
Effect on oocyst intensity
(%) (95% CI)
69.3% (65.7–73.1)
Effect on oocyst
prevalence
(%) (95% CI)
30.3% (28–32.6)
Effect on sporozoite
intensity (%)
(95% CI)
37.2% (23.6–48.4)
Effect on sporozoite
prevalence
(%) (95% CI)
46.5% (19.9–65.6)
Effect on subsequent
transmission to
the vertebrate host
Inhibition of infection
of naïve mice (%)
(P value, Fisher’s exact)
10.1% (0.075)
Prepatency (±SEM)
Compared to
6.1 days (±0.28)
in control mice
6.8 days (±0.28)
Effect size
(95% CI)
28.5% (22.8–33.7)