Table 1. Blood-brain barrier measurements in different regions of mouse brain.

The blood-to-brain influx constant (Kin) and volume of distribution (Vi) values of 3H-rHSP70 and 3H-albumin for different brain regions after intravenous injection in mice were calculated from the slope and y intercept in Fig. 2E.

Kin (ml/g per min)Vi (μl/mg)
Brain region3H-rHSP703H-Albumin3H-rHSP703H-Albumin
Whole brain3.0 × 10−58.8 × 10−60.01780.0219
Right and left hemispheres2.8 × 10−59.3 × 10−60.01740.0190
Cerebellum2.9 × 10−51.0 × 10−60.02250.0248
Midbrain3.9 × 10−51.1 × 10−50.01740.0213