Table 1. Natural selection.

Examples of approved drugs with causal support from tissue-specific human autoimmunity or human genetics. SOST, sclerostin; IL6R, interleukin 6 receptor; PCSK9, proprotein convertase subtilisin/kexin type 9; GLP1R, glucagon-like peptide–1 receptor; IL23A, interleukin 23α; IL12B, interleukin 12β.

Clinical disorderTissue-specific autoimmunityDrug
EncephalitisDRD2Antipsychotics
NarcolepsyOrexin neuronsSuvorexant
DiabetesPancreatic beta cellsInsulin
Myasthenia gravisAcetylcholine receptorsAcetylcholinesterase
inhibitors
Thrombotic thrombocytopenic
purpura
ADAMTS13 on plateletsCaplacizumab*
Clinical disorderGene(s)Drug(s)
SchizophreniaDRD2Antipsychotics
Sclerosteosis and van Buchem
disease
SOSTRomosozumab*
Rheumatoid arthritisIL6RTocilizumab
High cholesterolPCSK9Evolocumab and alirocumab
DiabetesGLP1RIncretin mimetics
PsoriasisIL23A, IL23R, and IL12BUstekinumab
Atopic dermatitisIL4RADupilumab*

*Not yet approved.