Table 1. Data sets used in the discovery and direct validation of the bacterial/viral metascore.

CAP, community-acquired pneumonia; HHV6, human herpesvirus 6; RSV, respiratory syncytial virus; HSV, herpes simplex virus; CMV, cytomegalovirus; MPV, metapneumovirus; PICU, pediatric intensive care unit; LRTI, lower respiratory tract infection; ARI, acute respiratory infection; COPD, chronic obstructive pulmonary disease.

AccessionAuthorTissuePlatformDemographicBacteriaVirusesNumber
healthy
Number
bacterial
Number
viral
A. Discovery data sets
GSE6269RamiloPBMCGPL2507Children
admitted
with
infection
Escherichia coli,
Staphylococcus aureus,
Streptococcus
pneumoniae
Influenza0168
GPL570S. aureus,
S. pneumoniae
Influenza01210
GPL96S. aureus,
S. pneumoniae
Influenza67318
GSE20346ParnellWhole bloodGPL6947Adults with
CAP
Unknown
bacterial
pneumonia
Influenza36128
GSE40012ParnellWhole bloodGPL6947Adults with
CAP
Unknown bacterial
pneumonia
Influenza183611
GSE40396HuWhole bloodGPL10558Febrile
children in
emergency
department
MultipleAdenovirus,
enterovirus,
rhinovirus,
HHV6
22835
GSE42026HerbegWhole bloodGPL6947Children admitted
with infection
Streptococcus and
Staphylococcus spp.
Influenza, RSV331841
GSE66099WongWhole bloodGPL570Septic children
in PICU
MultipleInfluenza, HSV,
CMV, BK,
adenovirus
4710911
B. Validation data sets
GSE15297PopperWhole bloodGPL8328Febrile
children
Scarlet fever
(Streptococcus)
Adenovirus058
GSE25504SmithWhole bloodGPL13667Septic
neonates
MultipleRhinovirus,
CMV
6113
GPL6947MultipleCMV35261
GSE60244SuarezWhole bloodGPL10558Adults hospitalized
with LRTI
Gram-positive and atypicalInfluenza, RSV, MPV402271
GSE63990TsalikWhole bloodGPL571Adults with ARIMultipleMultiple070115
E-MEXP-3589AlmansaWhole bloodGPL10332Adults with
COPD with
infection
Gram-positive,
Gram-negative,
atypical
Influenza, RSV, MPV445