Table 1. Human IgG subclass proportions of SAB-300, and SAB-301 antibodies.

Human IVIG, SAB-300, and SAB-301 were analyzed for the IgG subclass proportions by ELISA. Percentage of each subclass is presented as compared to the positive control. Chimeric antibodies (containing human κ and bovine heavy chain) were less than 1%, and other bovine proteins were less than 100 ppm.

AntibodyIgG1 (%)IgG2 (%)IgG3 (%)IgG4 (%)
Human IVIG*67262.62.5
SAB-300990.270.130.08
SAB-301936.20.070.05

*Human-derived IVIG served as the positive control and was run on the same IgG subclass ELISA plates with the other antibodies.