Table 1. Association of the mutant CXCR1-T276 allele with development of disseminated candidiasis after candidemia in patients of mixed European descent (n = 153).

ANC, absolute neutrophil count.

VariableUnivariate analysis
P value
Multivariate analysis
OR (95% CI)
CXCR1-T276 allele (CG + GG)0.04553.95 (1.20–13.03)
Male sex0.5264
Immunocompromised state0.2882
Hematopoietic stem cell transplantation0.5845*
Solid organ transplantation0.01024.03 (1.46–11.17)
Active malignancy0.3656
Solid tumor0.5967
Leukemia1.0000*
Lymphoma0.3124*
Chemotherapy within the past 3 months0.6836
Neutropenia (ANC < 500 cells/mm3)0.4837
Surgery within the past 30 days0.102
Receipt of total parenteral nutrition0.08913.19 (1.19–8.21)
Dialysis-dependent1.0000*
Acute renal failure0.2652
Liver disease0.1551
Intensive care unit admission within the past 14 days0.5278

*Fisher’s exact test.