NT, not tested.
Viral detection (culture) | Viral detection (qPCR) | % with indicated illness* | |||||||||||
Subjects | Dose (log10 PFU/ml) | No. of subjects | % Infected | % Shedding virus† | Peak titer mean (SD) log10 PFU/ml | Peak copy number log10 (SD) | Fever | URI | LRI | Cough | OM | Respiratory or febrile illness | Other |
Adults | |||||||||||||
Vaccinees | 6.0 | 15 | 0 | 0 | 0.6 (0.0) | NT | 0 | 20 | 0 | 7 | 0 | 20 | 27 |
Seropositive children | |||||||||||||
Vaccinees | 6.0 | 10 | 10 | 0 | 0.6 (0.0) | NT | 0 | 40 | 0 | 0 | 0 | 40 | 20 |
Placebo recipients | Placebo | 5 | 20 | 0 | 0.6 (0.0) | NT | 0 | 0 | 0 | 0 | 0 | 0 | 60 |
Seronegative children | |||||||||||||
Vaccinees | 5.0 | 20 | 95 | 85 | 1.5 (0.9) | 3.4 (0.9) | 20 | 85 | 0 | 35 | 5 | 85 | 45 |
Infected placebo recipient‡ | Placebo | 1 | 100 | 100 | 2.0 (0.0) | 3.3 (0.0) | 100 | 100 | 0 | 0 | 0 | 100 | 0 |
Placebo recipients | Placebo | 9 | 0 | 0 | 0.6 (0.0) | 1.7 (0.0) | 22 | 44 | 0 | 33 | 0 | 67 | 78 |
*Illness abbreviations and definitions are as described in the text. URI was defined as rhinorrhea, pharyngitis, or hoarseness, and LRI was defined as wheezing, rhonchi, or rales, or having been diagnosed with pneumonia or laryngotracheobronchitis (croup).
†% Shedding vaccine virus as detected by culture and/or rRT-qPCR. The limit of detection of vaccine virus was 0.6 log10 PFU/ml by culture, and 1.7 log10 copy numbers/ml by rRT-qPCR.
‡Data from the seronegative placebo recipient, as described in the text.